Press Release - January 7, 2026
Epistemic AI Analysis Reveals Strategic Business Decisions as the Leading Driver of Phase 3 Clinical Trial Terminations
A new study in Nature Reviews Drug Discovery shows late-stage failure rates have doubled since 2013, shifting from scientific to strategic catalysts. Epistemic AI research shows that while global trial initiations have climbed steadily since 2013, the rate of premature terminations in critical late-stage phases has grown at an even faster pace.